Diethyl 4-[5-(4-chlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
نویسندگان
چکیده
In the title compound, C(22)H(24)ClN(3)O(4), intra-molecular C-H⋯O and C-H⋯N hydrogen bonds form S(9) and S(7) ring motifs, respectively. The 1,4-dihydro-pyridine ring adopts a flattened boat conformation. The benzene ring makes a dihedral angle of 33.36 (6)° with the pyrazole ring. In the crystal, pairs of N-H⋯N hydrogen bonds link the mol-ecules into inversion dimers. The dimers are stacked in column along the a axis through N-H⋯O and C-H⋯N hydrogen bonds. The crystal packing also features C-H⋯π inter-actions involving the pyrazole ring.
منابع مشابه
Diethyl 2,6-dimethyl-4-[5-(4-methylphenyl)-1H-pyrazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate
In the title compound, C23H27N3O4, the dihydro-pyridine ring adopts a (1,4)B conformation. Intra-molecular C-H⋯O contacts occur. In the crystal, N-H⋯O and N-H⋯N hydrogen bonds and C-H⋯N contacts connect the mol-ecules into strands along the a-axis direction.
متن کاملDiethyl 4-[5-(biphenyl-4-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate ethanol monosolvate
In the title compound, C(28)H(29)N(3)O(4)·C(2)H(6)O, the benzene ring makes dihedral angles of 33.72 (13) and 32.86 (13)°, respectively, with the adjacent pyrazole and phenyl rings. In the crystal, the components are connected via inter-molecular N-H⋯O, N-H⋯N, O-H⋯O and C-H⋯O hydrogen bonds, forming a layer parallel to the bc plane.
متن کاملDiethyl 4-[2-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
In the title compound, C(23)H(27)N(3)O(5), the pyrazole ring is inclined at dihedral angles of 38.16 (6) and 80.80 (6)°, respectively, to the least-squares planes of the benzene and dihydro-pyridine rings. In the crystal, adjacent mol-ecules are linked via a pair of N-H⋯N hydrogen bonds, forming an inversion dimer. The dimers are stacked in a column along the a axis through N-H⋯O hydrogen bonds...
متن کاملDiethyl 2,6-dimethyl-4-(5-phenyl-1H-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate
In the title compound, C(22)H(25)N(3)O(4), the dihydro-pyridine ring adopts a flattened boat conformation. The pyrazole ring makes a dihedral angle of 29.04 (5)° with the benzene ring. The mol-ecular structure is stabilized by an intra-molecular C-H⋯O hydrogen bond which generates an S(9) ring motif. In the crystal, mol-ecules are linked via N-H⋯O and C-H⋯N hydrogen bonds into a two-dimensional...
متن کاملSynthesis and biological evaluation of some novel 1,4-dihydropyridines as potential antitubercular agents.
Recent studies showed that 1,4-dihydropyridine-3,5-dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity. In this study, we have synthesized new derivatives of 1,4-dihydropyridines bearing carbmethoxy and carbethoxy group at C-3 and C-5 of the 1,4-dihydropyridine ring. In addition, 1H-pyrazole ring is substituted at C-4 position. These analogues were synthesize...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012